Pre-Clinical Genome Editing @Cambridge
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Publications

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Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming
 J Yang,  S S Rajan,  M J. Friedrich,  Guocheng Lan,  Xiangang Zou, H Ponstingl,  D A. Garyfallos,  Pentao Liu, Allan Bradley and Emmanouil Metzakopian. Stem Cell Reports (2019) (12):1-15

CRISPR screens: the right tool for the job
A Russell. The CRISPR Journal 2019 (2)1:9-12

In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells
Jian Yang*, David J. Ryan*, Guocheng Lan*, Xiangang Zou and Pentao Liu. Nature Methods 2019 (14)2:350-378
*First equal Authors

Lrig 1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro
Pawel Schweiger, Ditte Clement, Mahalia Page, Troels Schepeler, Xiangang Zou, Gabor Sirokmány, Fiona M. Watt & Kim B. Jensen. Scientific Reports 2018 (8)1:15255

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
Aled J. Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa* and Masashi Narita*. Nature Communications 2018 (9):1840

Establishment of mouse expanded potential stem cells
Jian Yang*, David J. Ryan*, Wei Wang*, Jason Cheuk-Ho Tsang*, Guocheng Lan*, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu, Zhexin Zhu, Juexuan Wang, Aleksandra A. Kolodziejczyk, Lia S. Campos, Cui Wang, Fengtang Yang, Zhen Zhong, Beiyuan Fu, Melanie A. Eckersley-Maslin, Michael Woods, Yosuke Tanaka, Xi Chen, Adam C. Wilkinson, James Bussell, Jacqui White, Ramiro Ramirez-Solis, Wolf Reik, Berthold Göttgens, Sarah A. Teichmann, Patrick P. L. Tam, Hiromitsu Nakauchi, Xiangang Zou, Liming Lu & Pentao Liu. Nature 2017 (550):393-397
*First equal Authors

Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells
Judit Espana-Agusti, Xiangang Zou, Kim Wong, Beiyuan Fu, Fengtang Yang, David A. Tuveson, David J. Adams, Athena Matakidou. PLOS One 2016 (11)2: e0148055


Funding and Awards

2019
BRC III Pump Priming Award (Department of Medicine, University of Cambridge)

Development of a high throughput functional genomics platform for editing patient-derived PMBCs
Tiffeney Mann, Amy Smith, Alasdair Russell & James Thaventhiran

2018
Cancer Research UK Pioneer Award

Efficient 'on demand' generation of complex experimental transgenic mouse models
Liam Cassidy & Alasdair Russell

Genetics Society Summer Fellowship: in vitro prototyping of genome editing strategies to inform in vivo genome editing success
Isabel Esain Garcia
Isabel visited us for the Summer to combine E.coli transcription/translation systems, microfluidics, 3D printing and in vivo genome editing in what turned out to be a very exciting Summer project!
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  • Home
  • Science&Tech
  • The Team
    • Al Russell
  • Contact
  • Publications
  • Job Opportunities